BDBM50277936 (R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)propanoic acid::CHEMBL485023

SMILES C[C@@H](NC(=O)c1nc(Cl)c2ccccc2c1O)C(O)=O

InChI Key InChIKey=QJWFWOUODUTVCE-ZCFIWIBFSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50277936   

TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50277936((R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
Affinity DataIC50:  2.30E+5nMAssay Description:Inhibition of human PHD2 at 293K temperature by solvent relaxation techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50277936((R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50277936((R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
Affinity DataKd:  2.20E+4nMAssay Description:Binding affinity to human PHD2 by nondenaturing ESI-MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50277936((R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
Affinity DataKd:  2.20E+4nMAssay Description:Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperatureMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed