BDBM50279429 3-(4-Chloro-phenyl)-2-(4-methyl-2-methylamino-thiazol-5-yl)-3H-quinazolin-4-one::CHEMBL487336

SMILES CNc1nc(C)c(s1)-c1nc2ccccc2c(=O)n1-c1ccc(Cl)cc1

InChI Key InChIKey=AYXWCPYBVSRVPO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50279429   

TargetTranscription factor Jun(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50279429(3-(4-Chloro-phenyl)-2-(4-methyl-2-methylamino-thia...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of AP-1-mediated transcriptional activation in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50279429(3-(4-Chloro-phenyl)-2-(4-methyl-2-methylamino-thia...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of AP1 expressed in HEK293 cells assessed as inhibition of PMA-induced transcriptional activation treated 24 hrs before PMA challenge by l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50279429(3-(4-Chloro-phenyl)-2-(4-methyl-2-methylamino-thia...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of AP1 (unknown origin) expressed in HEK293 cells assessed as inhibition of TNFalpha-induced transcriptional activation treated 24 hrs bef...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed