BDBM50280749 CHEMBL4169454

SMILES Cn1cc(\C=C2/CC(CO)(COC(=O)C(C)(C)C)OC2=O)c2ccccc12

InChI Key InChIKey=NMSQMKXWQOPPRS-NTEUORMPSA-N

Data  3 KI  15 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50280749   

TargetRas guanyl-releasing protein 3(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]PDBu from full length recombinant human PKCepsilon expressed in baculovirus expression system after 5 mins by scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataKi:  127nMAssay Description:Displacement of [3H]PDBu from full length recombinant human PKCalpha expressed in baculovirus expression system after 5 mins by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas guanyl-releasing protein 3(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  6.09E+3nMAssay Description:Activation of RasGRP3 in human Ramos cells assessed as ERK1/2 phosphorylation after 30 mins by immunoblot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  8.28E+3nMAssay Description:Activation of PKCdelta (unknown origin) expressed in human LNCAP cells harboring GFP-tagged RasGRP3 assessed as phosphorylation at ser299 residues af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas guanyl-releasing protein 3(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  1.83E+3nMAssay Description:Activation of GFP-tagged RasGRP3 (unknown origin) expressed in HEK293 cells after 30 mins by immunoblot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAS guanyl-releasing protein 1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  970nMAssay Description:Activation of GFP-tagged RasGRP1 (unknown origin) expressed in human LNCAP cells after 30 mins by immunoblot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas guanyl-releasing protein 3(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  640nMAssay Description:Activation of GFP-tagged RasGRP3 (unknown origin) expressed in human LNCAP cells after 30 mins by immunoblot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  1.69E+4nMAssay Description:Activation of PKCdelta (unknown origin) expressed in HEK293 cells harboring GFP-tagged RasGRP3 assessed as phosphorylation at ser299 residues after 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  2.46E+4nMAssay Description:Activation of PKCdelta in human Ramos cells expressing RasGRP3 assessed as phosphorylation at ser299 residues after 30 mins by immunoblot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas guanyl-releasing protein 3(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  4.66E+3nMAssay Description:Activation of GFP-tagged RasGRP3 (unknown origin) expressed in HEK293 cells assessed as ERK1/2 phosphorylation after 30 mins by immunoblot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAS guanyl-releasing protein 1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  3.73E+3nMAssay Description:Activation of GFP-tagged RasGRP1 (unknown origin) expressed in human LNCAP cells assessed as ERK1/2 phosphorylation after 30 mins by immunoblot metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas guanyl-releasing protein 3(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  2.98E+3nMAssay Description:Activation of GFP-tagged RasGRP3 (unknown origin) expressed in human LNCAP cells assessed as ERK1/2 phosphorylation after 30 mins by immunoblot metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  1.26E+4nMAssay Description:Activation of PKCdelta (unknown origin) expressed in HEK293 cells harboring GFP-tagged RasGRP1 assessed as phosphorylation at ser299 residues after 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAS guanyl-releasing protein 1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  4.88E+3nMAssay Description:Activation of GFP-tagged RasGRP1 (unknown origin) expressed in HEK293 cells assessed as ERK1/2 phosphorylation after 30 mins by immunoblot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas guanyl-releasing protein 3(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  860nMAssay Description:Activation of RasGRP3 in human Ramos cells after 30 mins by immunoblot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  8.03E+3nMAssay Description:Activation of PKCdelta (unknown origin) expressed in human LNCAP cells harboring GFP-tagged RasGRP1 assessed as phosphorylation at ser299 residues af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAS guanyl-releasing protein 1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  860nMAssay Description:Activation of GFP-tagged RasGRP1 (unknown origin) expressed in HEK293 cells after 30 mins by immunoblot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed