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BDBM50286670 2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphthalen-1-yl-piperazin-1-yl)-ethanone::CHEMBL160581

SMILES: NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12

InChI Key: InChIKey=FYCXANKHKYEXTR-UHFFFAOYSA-N

Data: 3 KI  8 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50286670   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 1D


(Homo sapiens (human))
BDBM50286670
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2
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0.520n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined


Bioorg Med Chem Lett 5: 663-666 (1995)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50286670
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2
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0.950n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1A receptor was determined


Bioorg Med Chem Lett 5: 663-666 (1995)

More data for this
Ligand-Target Pair
Dopamine D2 receptor and serotonin 1a receptor


(Homo sapiens (human))
BDBM50286670
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2
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8.90n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1A receptor was determined


Bioorg Med Chem Lett 5: 663-666 (1995)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50286670
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its affinity towards dopaminergic (D2) receptor


Bioorg Med Chem Lett 5: 663-666 (1995)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(HUMAN M3)
BDBM50286670
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its affinity towards muscarinic (M) receptor


Bioorg Med Chem Lett 5: 663-666 (1995)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50286670
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2
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n/an/an/an/a 2.80n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta ...


Bioorg Med Chem Lett 5: 663-666 (1995)

More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C)


(Rattus norvegicus (Rat))
BDBM50286670
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its affinity towards 5-hydroxytryptamine 1C receptor


Bioorg Med Chem Lett 5: 663-666 (1995)

More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Homo sapiens (human))
BDBM50286670
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2
MMDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined


Bioorg Med Chem Lett 5: 663-666 (1995)

More data for this
Ligand-Target Pair
Adrenergic receptor alpha-1


(HUMAN-Homo sapiens (Human))
BDBM50286670
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2
MMDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its affinity towards Alpha-1 adrenergic receptor


Bioorg Med Chem Lett 5: 663-666 (1995)

More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50286670
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its affinity towards histaminergic (H 1) receptor


Bioorg Med Chem Lett 5: 663-666 (1995)

More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Rattus norvegicus)
BDBM50286670
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its affinity towards Alpha-2 adrenergic receptor


Bioorg Med Chem Lett 5: 663-666 (1995)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50286670
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its affinity towards 5-hydroxytryptamine 4 receptor


Bioorg Med Chem Lett 5: 663-666 (1995)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50286670
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2
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n/an/an/an/a 95n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1A receptor in...


Bioorg Med Chem Lett 5: 663-666 (1995)

More data for this
Ligand-Target Pair