BDBM50288323 4-(3-Trifluoromethyl-5H-isothiochromeno[4,3-c]pyrazol-1-yl)-benzenesulfonamide::CHEMBL329919

SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(c2SCc3ccccc3-c12)C(F)(F)F

InChI Key InChIKey=FOTJKGZGHZQSLX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50288323   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288323(4-(3-Trifluoromethyl-5H-isothiochromeno[4,3-c]pyra...)
Affinity DataIC50:  400nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50288323(4-(3-Trifluoromethyl-5H-isothiochromeno[4,3-c]pyra...)
Affinity DataIC50:  20nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50288323(4-(3-Trifluoromethyl-5H-isothiochromeno[4,3-c]pyra...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory concentration against Prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50288323(4-(3-Trifluoromethyl-5H-isothiochromeno[4,3-c]pyra...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288323(4-(3-Trifluoromethyl-5H-isothiochromeno[4,3-c]pyra...)
Affinity DataIC50:  400nMAssay Description:Inhibition of COX-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article