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BDBM50292411 (E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)pyridine::1-((E)-3-Pyridin-2-yl-3-p-tolyl-allyl)-pyrrolidinium::2-((E)-3-Pyrrolidin-1-yl-1-p-tolyl-propenyl)-pyridine::2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)pyridine::2-(3-Pyrrolidin-1-yl-1-p-tolyl-propenyl)-pyridine::Actahist::Actidil::Actifed::Allerfed::CHEMBL855::Corphed::Histafed::Myfed::Myidyl::TRIPROLIDINE::Triacin-C::Trilitron::Triphed::Triprolidin

SMILES: Cc1ccc(cc1)C(=C/CN1CCCC1)\c1ccccn1

InChI Key: InChIKey=CBEQULMOCCWAQT-WOJGMQOQSA-N

Data: 9 KI  1 Kd

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50292411   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50292411
PNG
((E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)py...)
Show SMILES Cc1ccc(cc1)C(=C/CN1CCCC1)\c1ccccn1
Show InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
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PubMed
0.310n/an/an/an/an/an/an/an/a



Université Libre de Bruxelles

Curated by PDSP Ki Database




Eur J Biochem 224: 489-95 (1994)

More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50292411
PNG
((E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)py...)
Show SMILES Cc1ccc(cc1)C(=C/CN1CCCC1)\c1ccccn1
Show InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
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PubMed
0.690n/an/an/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 328-36 (2002)

More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50292411
PNG
((E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)py...)
Show SMILES Cc1ccc(cc1)C(=C/CN1CCCC1)\c1ccccn1
Show InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
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PubMed
0.930n/an/an/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 328-36 (2002)

More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50292411
PNG
((E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)py...)
Show SMILES Cc1ccc(cc1)C(=C/CN1CCCC1)\c1ccccn1
Show InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
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1n/an/an/an/an/an/an/an/a



Université Libre de Bruxelles

Curated by PDSP Ki Database




Eur J Biochem 224: 489-95 (1994)

More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50292411
PNG
((E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)py...)
Show SMILES Cc1ccc(cc1)C(=C/CN1CCCC1)\c1ccccn1
Show InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
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Article
PubMed
1n/an/an/an/an/an/an/an/a



Universite Libre de Bruxelles

Curated by PDSP Ki Database




J Recept Signal Transduct Res 15: 91-102

More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50292411
PNG
((E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)py...)
Show SMILES Cc1ccc(cc1)C(=C/CN1CCCC1)\c1ccccn1
Show InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
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PubMed
1.11n/an/an/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 328-36 (2002)

More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50292411
PNG
((E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)py...)
Show SMILES Cc1ccc(cc1)C(=C/CN1CCCC1)\c1ccccn1
Show InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
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PubMed
1.53n/an/an/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 328-36 (2002)

More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50292411
PNG
((E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)py...)
Show SMILES Cc1ccc(cc1)C(=C/CN1CCCC1)\c1ccccn1
Show InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
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Article
PubMed
1.60n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from histamine H1 receptor


J Nat Prod 56: 441-455 (1993)

More data for this
Ligand-Target Pair
Histamine H1 receptor


(RAT)
BDBM50292411
PNG
((E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)py...)
Show SMILES Cc1ccc(cc1)C(=C/CN1CCCC1)\c1ccccn1
Show InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
KEGG

UniProtKB/SwissProt

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PubMed
5.60n/an/an/an/an/an/an/an/a



TBA

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 75: 6290-4 (1978)

More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50292411
PNG
((E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)py...)
Show SMILES Cc1ccc(cc1)C(=C/CN1CCCC1)\c1ccccn1
Show InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
UniProtKB/SwissProt

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PubMed
n/an/an/a 0.126n/an/an/an/an/a



Vrije Universiteit

Curated by ChEMBL


Assay Description
Potency against histamine H1 receptor on guinea pig ileum


J Med Chem 38: 3351-60 (1995)

More data for this
Ligand-Target Pair