BDBM50292630 (23R)-25-dehydro-2-methylene-19-nor-1alpha-hydroxyvitaminD3-26,23-lactone::(5R)-5-{(2R)-2-[(1R,3R,7E)-1,3-Dihydroxy-2-methylene-9,10-secoestra-5,7-dien-17-yl]propyl}-3-methylenedihydro-2(3H)-furanone::CHEMBL261197

SMILES [#6]-[#6@H](-[#6]-[#6@@H]-1-[#6]-[#6](=[#6])-[#6](=O)-[#8]-1)-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1

InChI Key InChIKey=NFEAURPDDCSCJD-AZRXGHRDSA-N

Data  1 KI  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50292630   

TargetVitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50292630((23R)-25-dehydro-2-methylene-19-nor-1alpha-hydroxy...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50292630((23R)-25-dehydro-2-methylene-19-nor-1alpha-hydroxy...)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human VDR in HEK293 cells assessed as induction of transcriptional transactivation after 24 hrs by mouse osteopontin luciferase r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50292630((23R)-25-dehydro-2-methylene-19-nor-1alpha-hydroxy...)
Affinity DataIC50:  300nMAssay Description:Antagonist activity at human VDR in HEK293 cells assessed as induction of transcriptional transactivation after 24 hrs by mouse osteopontin luciferas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50292630((23R)-25-dehydro-2-methylene-19-nor-1alpha-hydroxy...)
Affinity DataEC50:  150nMAssay Description:Agonist activity at human VDR in COS7 cells assessed as induction of transcriptional transactivation after 24 hrs by mouse osteopontin luciferase rep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50292630((23R)-25-dehydro-2-methylene-19-nor-1alpha-hydroxy...)
Affinity DataIC50:  1.00E+3nMAssay Description:Antagonist activity at human VDR in COS7 cells assessed as induction of transcriptional transactivation after 24 hrs by mouse osteopontin luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50292630((23R)-25-dehydro-2-methylene-19-nor-1alpha-hydroxy...)
Affinity DataEC50:  100nMAssay Description:Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50292630((23R)-25-dehydro-2-methylene-19-nor-1alpha-hydroxy...)
Affinity DataEC50:  20nMAssay Description:Displacement of [3H]1,25-(OH)2D3 from rat recombinant His-tagged VDR ligand-binding domain expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed