BDBM50293174 (trans)-N1-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)cyclohexane-1,4-diamine::CHEMBL496567

SMILES CC(C)(C)c1cnc(CSc2cnc(N[C@H]3CC[C@H](N)CC3)s2)o1

InChI Key InChIKey=JFSGUSJACVSEKX-HAQNSBGRSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50293174   

TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293174((trans)-N1-(5-((5-tert-butyloxazol-2-yl)methylthio...)
Affinity DataIC50:  355nMAssay Description:Inhibition of CDK9 in human HCT116 cells assessed as phosphor-ser2 level of RNA polymerase 2 after 16 hrs by high content cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293174((trans)-N1-(5-((5-tert-butyloxazol-2-yl)methylthio...)
Affinity DataIC50:  763nMAssay Description:Inhibition of CDK1/cyclin B by IMAP florescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293174((trans)-N1-(5-((5-tert-butyloxazol-2-yl)methylthio...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CDK2/cyclin A by IMAP florescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293174((trans)-N1-(5-((5-tert-butyloxazol-2-yl)methylthio...)
Affinity DataIC50:  105nMAssay Description:Inhibition of CDK7/cyclinH by IMAP florescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293174((trans)-N1-(5-((5-tert-butyloxazol-2-yl)methylthio...)
Affinity DataIC50:  97nMAssay Description:Inhibition of CDK9/cyclinT by IMAP florescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed