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BDBM50293745 2-(4-sulfamoylphenylamino)-1-(1-(2-(trifluoromethyl)phenyl)ethyl)-1H-benzo[d]imidazole-5-carboxamide::CHEMBL552298

SMILES: CC(c1ccccc1C(F)(F)F)n1c(Nc2ccc(cc2)S(N)(=O)=O)nc2cc(ccc12)C(N)=O

InChI Key: InChIKey=MBTCJFAQKYTMFO-UHFFFAOYSA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50293745   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kinesin-like protein 1


(Homo sapiens)
BDBM50293745
PNG
(2-(4-sulfamoylphenylamino)-1-(1-(2-(trifluoromethy...)
Show SMILES CC(c1ccccc1C(F)(F)F)n1c(Nc2ccc(cc2)S(N)(=O)=O)nc2cc(ccc12)C(N)=O
Show InChI InChI=1S/C23H20F3N5O3S/c1-13(17-4-2-3-5-18(17)23(24,25)26)31-20-11-6-14(21(27)32)12-19(20)30-22(31)29-15-7-9-16(10-8-15)35(28,33)34/h2-13H,1H3,(H2,27,32)(H,29,30)(H2,28,33,34)
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PC sid
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Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human kinesin spindle protein by endpoint assay


Bioorg Med Chem Lett 19: 3405-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.040
BindingDB Entry DOI: 10.7270/Q2MS3SS3
More data for this
Ligand-Target Pair
Kinesin heavy chain isoform 5A


(Homo sapiens)
BDBM50293745
PNG
(2-(4-sulfamoylphenylamino)-1-(1-(2-(trifluoromethy...)
Show SMILES CC(c1ccccc1C(F)(F)F)n1c(Nc2ccc(cc2)S(N)(=O)=O)nc2cc(ccc12)C(N)=O
Show InChI InChI=1S/C23H20F3N5O3S/c1-13(17-4-2-3-5-18(17)23(24,25)26)31-20-11-6-14(21(27)32)12-19(20)30-22(31)29-15-7-9-16(10-8-15)35(28,33)34/h2-13H,1H3,(H2,27,32)(H,29,30)(H2,28,33,34)
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UniChem

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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of nKHC


Bioorg Med Chem Lett 19: 3405-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.040
BindingDB Entry DOI: 10.7270/Q2MS3SS3
More data for this
Ligand-Target Pair
Kinesin-like protein KIF3B


(Homo sapiens)
BDBM50293745
PNG
(2-(4-sulfamoylphenylamino)-1-(1-(2-(trifluoromethy...)
Show SMILES CC(c1ccccc1C(F)(F)F)n1c(Nc2ccc(cc2)S(N)(=O)=O)nc2cc(ccc12)C(N)=O
Show InChI InChI=1S/C23H20F3N5O3S/c1-13(17-4-2-3-5-18(17)23(24,25)26)31-20-11-6-14(21(27)32)12-19(20)30-22(31)29-15-7-9-16(10-8-15)35(28,33)34/h2-13H,1H3,(H2,27,32)(H,29,30)(H2,28,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Kif3B


Bioorg Med Chem Lett 19: 3405-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.040
BindingDB Entry DOI: 10.7270/Q2MS3SS3
More data for this
Ligand-Target Pair