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BDBM50293749 1-(2,3-dimethoxybenzyl)-2-(4-sulfamoylphenylamino)-1H-benzo[d]imidazole-5-carboxamide::CHEMBL564451

SMILES: COc1cccc(Cn2c(Nc3ccc(cc3)S(N)(=O)=O)nc3cc(ccc23)C(N)=O)c1OC

InChI Key: InChIKey=RPCHBCSSYSNRNY-UHFFFAOYSA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50293749   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kinesin-like protein 1


(Homo sapiens)
BDBM50293749
PNG
(1-(2,3-dimethoxybenzyl)-2-(4-sulfamoylphenylamino)...)
Show SMILES COc1cccc(Cn2c(Nc3ccc(cc3)S(N)(=O)=O)nc3cc(ccc23)C(N)=O)c1OC
Show InChI InChI=1S/C23H23N5O5S/c1-32-20-5-3-4-15(21(20)33-2)13-28-19-11-6-14(22(24)29)12-18(19)27-23(28)26-16-7-9-17(10-8-16)34(25,30)31/h3-12H,13H2,1-2H3,(H2,24,29)(H,26,27)(H2,25,30,31)
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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human kinesin spindle protein by endpoint assay


Bioorg Med Chem Lett 19: 3405-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.040
BindingDB Entry DOI: 10.7270/Q2MS3SS3
More data for this
Ligand-Target Pair
Kinesin heavy chain isoform 5A


(Homo sapiens)
BDBM50293749
PNG
(1-(2,3-dimethoxybenzyl)-2-(4-sulfamoylphenylamino)...)
Show SMILES COc1cccc(Cn2c(Nc3ccc(cc3)S(N)(=O)=O)nc3cc(ccc23)C(N)=O)c1OC
Show InChI InChI=1S/C23H23N5O5S/c1-32-20-5-3-4-15(21(20)33-2)13-28-19-11-6-14(22(24)29)12-18(19)27-23(28)26-16-7-9-17(10-8-16)34(25,30)31/h3-12H,13H2,1-2H3,(H2,24,29)(H,26,27)(H2,25,30,31)
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PC sid
UniChem

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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of nKHC


Bioorg Med Chem Lett 19: 3405-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.040
BindingDB Entry DOI: 10.7270/Q2MS3SS3
More data for this
Ligand-Target Pair
Kinesin-like protein KIF3B


(Homo sapiens)
BDBM50293749
PNG
(1-(2,3-dimethoxybenzyl)-2-(4-sulfamoylphenylamino)...)
Show SMILES COc1cccc(Cn2c(Nc3ccc(cc3)S(N)(=O)=O)nc3cc(ccc23)C(N)=O)c1OC
Show InChI InChI=1S/C23H23N5O5S/c1-32-20-5-3-4-15(21(20)33-2)13-28-19-11-6-14(22(24)29)12-18(19)27-23(28)26-16-7-9-17(10-8-16)34(25,30)31/h3-12H,13H2,1-2H3,(H2,24,29)(H,26,27)(H2,25,30,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Kif3B


Bioorg Med Chem Lett 19: 3405-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.040
BindingDB Entry DOI: 10.7270/Q2MS3SS3
More data for this
Ligand-Target Pair