BDBM50295275 2-(2-(2-chlorophenylamino)phenyl)acetic acid::CHEMBL77823::[2-(2-Chloro-phenylamino)-phenyl]-acetic acid

SMILES OC(=O)Cc1ccccc1Nc1ccccc1Cl

InChI Key InChIKey=RXRLPBIKRNGLJD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50295275   

TargetInterleukin-8(Homo sapiens (Human))
Grupo Uriach

Curated by ChEMBL
LigandPNGBDBM50295275(2-(2-(2-chlorophenylamino)phenyl)acetic acid | CHE...)
Affinity DataIC50:  400nMAssay Description:Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50295275(2-(2-(2-chlorophenylamino)phenyl)acetic acid | CHE...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of purified mouse COX-2 assessed as inhibition of PGE2-G/PGD2-G formation preincubated for 3 mins before 2-AG substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(Homo sapiens (Human))TBA
LigandPNGBDBM50295275(2-(2-(2-chlorophenylamino)phenyl)acetic acid | CHE...)
Affinity DataIC50:  4.90E+6nMAssay Description:Inhibition of COX (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1/2(Bos taurus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50295275(2-(2-(2-chlorophenylamino)phenyl)acetic acid | CHE...)
Affinity DataIC50:  4.90E+6nMAssay Description:In vitro inhibition of bovine prostaglandin G/H synthase, using bovine seminal vesicle microsomal preparations; IC50 in umol/LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed