BDBM50296742 1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl carbamate::CHEMBL559478

SMILES Brc1ccc(OC(=O)N2CCN3CCC2CC3)cc1

InChI Key InChIKey=RXLOZRCLQMJJLC-UHFFFAOYSA-N

Data  6 KI  3 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50296742   

TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]alpha-BTX from human alpha7 nAChR expressed in rat GH4C1 cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataKi:  14nMAssay Description:Binding affinity to human alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataKi:  14nMAssay Description:Binding affinity to human alpha7 nAchRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataKi:  22nMAssay Description:Binding affinity to rat alpha7 nAchRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]alpha-bungarotoxin from Sprague-Dawley rat brain alpha7-nAChR after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataKi:  38nMAssay Description:Displacement of [125I]BTX from rat alpha7 nAChR expressed in rat GH4C1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataIC50: >3.16E+3nMAssay Description:Displacement of [3H]LY278584 from human 5HT3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataIC50: >6.48E+3nMAssay Description:Displacement of [3H]epibatidine from alpha3 nAChR in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataIC50: >5.00E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataEC50:  900nMAssay Description:Partial agonist activity at human alpha7 nAChR expressed in GH4C1 cells relative to acetylcholineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataEC50:  4.40E+3nMAssay Description:Partial agonist activity at human alpha7 nAChR expressed in Xenopus oocytes relative to acetylcholineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataEC50:  4.40E+3nMAssay Description:Partial agonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as evoked ACh-induced current by voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed