BDBM50296850 2-(1-(3-cyano-4-fluorophenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid::CHEMBL559044

SMILES Cc1c(CC(O)=O)c2cccnc2n1S(=O)(=O)c1ccc(F)c(c1)C#N

InChI Key InChIKey=XRMUPVMLIVXXAW-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50296850   

TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50296850(2-(1-(3-cyano-4-fluorophenylsulfonyl)-2-methyl-1H-...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50296850(2-(1-(3-cyano-4-fluorophenylsulfonyl)-2-methyl-1H-...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity against CRTh2 receptor in human whole blood assessed as eosinophil shape changeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50296850(2-(1-(3-cyano-4-fluorophenylsulfonyl)-2-methyl-1H-...)
Affinity DataIC50:  101nMAssay Description:Antagonist activity against human CRTh2 receptor expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50296850(2-(1-(3-cyano-4-fluorophenylsulfonyl)-2-methyl-1H-...)
Affinity DataIC50:  8nMAssay Description:Antagonist activity against CRTh2 receptor in human eosinophils assessed as cell shape changeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed