BDBM50297147 ((R)-7-Methyl-9-oxo-6,7,8,9-tetrahydro-5H-10-thia-5,8-diaza-benzo[a]azulen-3-yloxy)-acetic acid methyl ester::CHEMBL559881

SMILES COC(=O)COc1ccc2sc3c(NC[C@@H](C)NC3=O)c2c1

InChI Key InChIKey=PCQUNTVDQZZICH-MRVPVSSYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50297147   

TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297147(((R)-7-Methyl-9-oxo-6,7,8,9-tetrahydro-5H-10-thia-...)
Affinity DataIC50:  3.44E+3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297147(((R)-7-Methyl-9-oxo-6,7,8,9-tetrahydro-5H-10-thia-...)
Affinity DataIC50:  7.80E+4nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297147(((R)-7-Methyl-9-oxo-6,7,8,9-tetrahydro-5H-10-thia-...)
Affinity DataIC50:  3.09E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed