BDBM50297325 CHEMBL556439::N,N-Diethyl-4-(spiro[chromene-2,3'-pyrrolidine]-4-yl)benzamide

SMILES CCN(CC)C(=O)c1ccc(cc1)C1=CC2(CCNC2)Oc2ccccc12

InChI Key InChIKey=VJIOWLHENKXJHM-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50297325   

TargetDelta-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50297325(CHEMBL556439 | N,N-Diethyl-4-(spiro[chromene-2,3'-...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50297325(CHEMBL556439 | N,N-Diethyl-4-(spiro[chromene-2,3'-...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human CYP2D6 by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50297325(CHEMBL556439 | N,N-Diethyl-4-(spiro[chromene-2,3'-...)
Affinity DataIC50:  6.43E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells by voltage clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50297325(CHEMBL556439 | N,N-Diethyl-4-(spiro[chromene-2,3'-...)
Affinity DataEC50:  28nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed