BDBM50302165 3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno[2,3-b]pyridine-2-carboxamide::CHEMBL576887

SMILES CCCc1cc(nc2sc(C(N)=O)c(N)c12)N1CCC(O)CC1

InChI Key InChIKey=FTSQTLCAVRPYJK-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50302165   

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of ItkMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of BtkMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of FGFR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of HekMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of HGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of IKKalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50:  280nMAssay Description:Inhibition of Flag epitope-tagged IKK-beta preincubated for 5 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of SykMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of TrkAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302165(3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno...)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of EckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed