BDBM50302897 (S)-7-methoxy-4-(1-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethoxy)quinoline::CHEMBL585293::US9066954, 164

SMILES COc1ccc2c(O[C@@H](C)c3nnc4ccc(nn34)-c3ccccc3)ccnc2c1

InChI Key InChIKey=FKNPFDGOZHGKTD-HNNXBMFYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50302897   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50302897((S)-7-methoxy-4-(1-(6-phenyl-[1,2,4]triazolo[4,3-b...)
Affinity DataKi:  141nM ΔG°:  -9.40kcal/molepH: 8.0 T: 2°CAssay Description:A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302897((S)-7-methoxy-4-(1-(6-phenyl-[1,2,4]triazolo[4,3-b...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50302897((S)-7-methoxy-4-(1-(6-phenyl-[1,2,4]triazolo[4,3-b...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human CYP3A4 in human liver microsomes preincubated with NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50302897((S)-7-methoxy-4-(1-(6-phenyl-[1,2,4]triazolo[4,3-b...)
Affinity DataIC50:  104nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed