BDBM50302908 1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one::2-(N,N-Dimethylamino)-3'-chloropropiophenone::CHEMBL566830

SMILES CC(N(C)C)C(=O)c1cccc(Cl)c1

InChI Key InChIKey=UYZAXUWVJGHEFL-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50302908   

TargetSodium-dependent noradrenaline transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302908(1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one |...)
Affinity DataKi:  3.09E+3nMAssay Description:Displacement of [125I]RTI55 from cloned human NET expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302908(1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one |...)
Affinity DataKi:  4.13E+3nMAssay Description:Displacement of [125I]RTI55 from cloned human DAT expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302908(1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one |...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]RTI55 from cloned human SERT expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302908(1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one |...)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302908(1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one |...)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302908(1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one |...)
Affinity DataIC50: >100nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302908(1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one |...)
Affinity DataIC50:  1.53E+3nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302908(1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one |...)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302908(1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one |...)
Affinity DataIC50: >100nMAssay Description:Inhibition of [3H]serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed