BDBM50302930 1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one::2-(N-tert-Butylamino)-3'-bromopropiophenone::CHEMBL565396

SMILES CC(NC(C)(C)C)C(=O)c1cccc(Br)c1

InChI Key InChIKey=GIDJZDYNVHMFAH-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50302930   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302930(1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one ...)
Affinity DataKi:  4.20E+3nMAssay Description:Displacement of [125I]RTI55 from cloned human DAT expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302930(1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one ...)
Affinity DataKi: >7.14E+3nMAssay Description:Displacement of [125I]RTI55 from cloned human NET expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302930(1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one ...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]RTI55 from cloned human SERT expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302930(1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one ...)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302930(1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one ...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302930(1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one ...)
Affinity DataIC50:  511nMAssay Description:Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302930(1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one ...)
Affinity DataIC50: >100nMAssay Description:Inhibition of [3H]serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302930(1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one ...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302930(1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one ...)
Affinity DataIC50:  950nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed