BDBM50303052 (S)-N6-(1-(5-fluoropyridin-2-yl)ethyl)-3-methyl-N2-(5-methyl-1H-pyrazol-3-yl)pyrazine-2,6-diamine::CHEMBL576068

SMILES C[C@H](Nc1cnc(C)c(Nc2cc(C)n[nH]2)n1)c1ccc(F)cn1

InChI Key InChIKey=OGOUUWVUPLCXQA-JTQLQIEISA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50303052   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303052((S)-N6-(1-(5-fluoropyridin-2-yl)ethyl)-3-methyl-N2...)
Affinity DataIC50:  18nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303052((S)-N6-(1-(5-fluoropyridin-2-yl)ethyl)-3-methyl-N2...)
Affinity DataIC50:  3.66E+3nMAssay Description:Inhibition of JAK3 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303052((S)-N6-(1-(5-fluoropyridin-2-yl)ethyl)-3-methyl-N2...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed