BDBM50303441 9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-carbonitrile::CHEMBL567134

SMILES CCNc1nc(nc2n(cnc12)-c1cc(F)cc(F)c1)C#N

InChI Key InChIKey=VLZYXSQGILGQAI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50303441   

TargetCruzipain(Trypanosoma cruzi)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303441(9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-...)
Affinity DataIC50:  251nMAssay Description:Inhibition of Trypanosoma cruzi cruzain after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303441(9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-...)
Affinity DataIC50:  1.78E+5nMAssay Description:Inhibition of human Kallikrein 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303441(9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-...)
Affinity DataIC50:  7.08E+4nMAssay Description:Inhibition of human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303441(9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-...)
Affinity DataIC50:  316nMAssay Description:Inhibition of human Cathepsin X/ZMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303441(9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-...)
Affinity DataIC50:  33.1nMAssay Description:Inhibition of papaya papainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303441(9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-...)
Affinity DataIC50:  1.35E+5nMAssay Description:Inhibition of human MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303441(9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-...)
Affinity DataIC50:  589nMAssay Description:Inhibition of human Cathepsin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed