BDBM50303718 5-Adamantan-1-yl-2-amino-3-methyl-5-phenyl-3,5-dihydro-imidazol-4-one::CHEMBL585952

SMILES CN1C(N)=NC(C1=O)(c1ccccc1)C12CC3CC(CC(C3)C1)C2

InChI Key InChIKey=BEDDENNXVBITIQ-UHFFFAOYSA-N

Data  4 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50303718   

TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303718(5-Adamantan-1-yl-2-amino-3-methyl-5-phenyl-3,5-dih...)
Affinity DataIC50:  1.53E+3nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303718(5-Adamantan-1-yl-2-amino-3-methyl-5-phenyl-3,5-dih...)
Affinity DataEC50:  930nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303718(5-Adamantan-1-yl-2-amino-3-methyl-5-phenyl-3,5-dih...)
Affinity DataIC50:  2.73E+4nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303718(5-Adamantan-1-yl-2-amino-3-methyl-5-phenyl-3,5-dih...)
Affinity DataIC50:  830nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303718(5-Adamantan-1-yl-2-amino-3-methyl-5-phenyl-3,5-dih...)
Affinity DataIC50:  1.53E+3nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair