BDBM50303731 (5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3-methyl-5-[4-(trifluoromethoxy)phenyl]-3,5-dihydro-4H-imidazol-4-one::(R)-2-amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-1-methyl-4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-5(4H)-one::CHEMBL568115

SMILES CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)(F)F)cc1)c1ccc(F)c(c1)-c1cncnc1

InChI Key InChIKey=RNJTYVPMRSKRKE-HXUWFJFHSA-N

Data  7 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50303731   

TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataEC50:  70nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  4.18E+3nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataEC50:  270nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  9.69E+3nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  7.54E+3nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataEC50:  20nMAssay Description:Inhibition of BACE1 by cell-based assayMore data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  2.33E+3nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair