BDBM50303732 5-Adamantan-1-yl-2-amino-3-methyl-5-(4-trifluoromethoxy-phenyl)-3,5-diydro-imidazol-4-one::CHEMBL583899

SMILES CN1C(N)=NC(C1=O)(c1ccc(OC(F)(F)F)cc1)C12CC3CC(CC(C3)C1)C2

InChI Key InChIKey=KKUVYLRKCGXDSS-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50303732   

TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303732(5-Adamantan-1-yl-2-amino-3-methyl-5-(4-trifluorome...)
Affinity DataIC50:  470nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303732(5-Adamantan-1-yl-2-amino-3-methyl-5-(4-trifluorome...)
Affinity DataEC50:  900nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303732(5-Adamantan-1-yl-2-amino-3-methyl-5-(4-trifluorome...)
Affinity DataIC50:  6.22E+3nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303732(5-Adamantan-1-yl-2-amino-3-methyl-5-(4-trifluorome...)
Affinity DataIC50:  3.87E+3nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303732(5-Adamantan-1-yl-2-amino-3-methyl-5-(4-trifluorome...)
Affinity DataIC50:  470nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed