BDBM50304410 CHEMBL594108::cis-2-[(E)-4-(1H-Imidazol-1-yl)but-2-enyl]-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one

SMILES COc1ccc(cc1OC)C1=NN(C\C=C\Cn2ccnc2)C(=O)[C@@H]2CC=CC[C@H]12

InChI Key InChIKey=IGHBBDMZIFZXDF-OBNUAKFSSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50304410   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304410(CHEMBL594108 | cis-2-[(E)-4-(1H-Imidazol-1-yl)but-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed