BDBM50304417 CHEMBL593656::CHEMBL593877::cis-(+/-)-4-(3,4-Dimethoxyphenyl)-2-[4-(morpholinomethyl)benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one::cis-(-)-4-(3,4-Dimethoxyphenyl)-2-[4-(morpholinomethyl)benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one

SMILES COc1ccc(cc1OC)C1=NN(Cc2ccc(CN3CCOCC3)cc2)C(=O)[C@@H]2CC=CC[C@H]12

InChI Key InChIKey=FGIZZKGOFBXORG-BJKOFHAPSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50304417   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304417(CHEMBL593656 | CHEMBL593877 | cis-(+/-)-4-(3,4-Dim...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304417(CHEMBL593656 | CHEMBL593877 | cis-(+/-)-4-(3,4-Dim...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304417(CHEMBL593656 | CHEMBL593877 | cis-(+/-)-4-(3,4-Dim...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed