BDBM50304738 2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedioic acid::CHEMBL596351::US20230414794, Compound ZJ-43

SMILES CC(C)C[C@H](NC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O

InChI Key InChIKey=BSGWCSGMXAVYRT-YUMQZZPRSA-N

Data  4 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50304738   

TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50304738(2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedi...)
Affinity DataKi:  0.580nMAssay Description:Inhibition of antiTEV-tagged GCP2 extracellular portion (aa 44-750) (unknown origin) using folyl-di-L-glutamate as substrate by HPLC-based enzymatic ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50304738(2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedi...)
Affinity DataKi:  0.75nMAssay Description:Inhibition of human cloned glutamate carboxypeptidase 2More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50304738(2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedi...)
Affinity DataKi:  1.08nMAssay Description:Inhibition of glutamate carboxypeptidase 2 in human LNCAP cells assessed as glutamate formation using NAAG as substrate after 60 mins by fluorometric...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50304738(2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedi...)
Affinity DataKi:  3.53nMAssay Description:This test example is used to display the results of the PSMA inhibitory activity tested for each compound and comparative compound. A LNCaP cell lysa...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50304738(2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedi...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50304738(2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedi...)
Affinity DataIC50:  11nMAssay Description:Inhibition of PSMA in human LNCaP cell extracts using NAAG as substrate by amplex red reagent based assayMore data for this Ligand-Target Pair