BDBM50305293 (3-(9-(1-(4-(3-(dimethylamino)propoxy)benzyl)piperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenyl)methanol::CHEMBL602184

SMILES CN(C)CCCOc1ccc(CN2CCC(CC2)n2cnc3c(nc(nc23)-c2cccc(CO)c2)N2CCOCC2)cc1

InChI Key InChIKey=PPKZLTMKAKJNMK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50305293   

LigandPNGBDBM50305293((3-(9-(1-(4-(3-(dimethylamino)propoxy)benzyl)piper...)
Affinity DataIC50:  16nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305293((3-(9-(1-(4-(3-(dimethylamino)propoxy)benzyl)piper...)
Affinity DataIC50:  300nMAssay Description:Inhibition of PI3Kalpha in human MDA-MB-361 cells assessed as reduction of phosphorylated Akt (T308) level after 4 hrs by western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305293((3-(9-(1-(4-(3-(dimethylamino)propoxy)benzyl)piper...)
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305293((3-(9-(1-(4-(3-(dimethylamino)propoxy)benzyl)piper...)
Affinity DataIC50:  265nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed