BDBM50308129 4-{(1S)-1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}-carbonyl)amino]ethyl}benzoic acid::CHEMBL603690

SMILES C[C@H](NC(=O)c1c(C)sc(C)c1Cc1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(O)=O

InChI Key InChIKey=DOTIWNYTQPDMBR-ZDUSSCGKSA-N

Data  10 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50308129   

TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Canada

US Patent
LigandPNGBDBM50308129(4-{(1S)-1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)be...)
Affinity DataKi:  1.40nM ΔG°:  -12.1kcal/molepH: 6.0 T: 2°CAssay Description:Transfected HEK 293(ebna) cells are maintained in culture, harvested and membranes are prepared by differential centrifugation, following lysis of th...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Canada

US Patent
LigandPNGBDBM50308129(4-{(1S)-1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)be...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308129(4-{(1S)-1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)be...)
Affinity DataKi:  1.19E+3nMAssay Description:Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308129(4-{(1S)-1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)be...)
Affinity DataKi: >5.47E+3nMAssay Description:Displacement of [3H]iloprost from human IP receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308129(4-{(1S)-1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)be...)
Affinity DataKi: >5.47E+3nMAssay Description:Displacement of [3H]SQ29548 from human TP receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308129(4-{(1S)-1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)be...)
Affinity DataKi: >5.47E+3nMAssay Description:Displacement of [3H]PGF2alpha from human FP receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308129(4-{(1S)-1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)be...)
Affinity DataKi: >5.47E+3nMAssay Description:Displacement of [3H]PGD2 from human DP1 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308129(4-{(1S)-1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)be...)
Affinity DataKi: >5.47E+3nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308129(4-{(1S)-1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)be...)
Affinity DataKi: >5.47E+3nMAssay Description:Displacement of [3H]PGD2 from human DP2 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308129(4-{(1S)-1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)be...)
Affinity DataKi: >5.47E+3nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Canada

US Patent
LigandPNGBDBM50308129(4-{(1S)-1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)be...)
Affinity DataIC50:  4.5nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed