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BDBM50308559 3-((1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-1-(2-propoxyethyl)-7-(6-methoxypyridin-3-yl)pyrido[3,4-b]pyrazin-2(1H)-one::CHEMBL602120

SMILES: CCCOCCn1c2cc(ncc2nc(N2C[C@H]3C[C@@H]2CN3)c1=O)-c1ccc(OC)nc1

InChI Key: InChIKey=QDIQYFQPTWVPLK-IAGOWNOFSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308559   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50308559
PNG
(3-((1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-1-(...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2C[C@H]3C[C@@H]2CN3)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C23H28N6O3/c1-3-7-32-8-6-28-20-10-18(15-4-5-21(31-2)26-11-15)25-13-19(20)27-22(23(28)30)29-14-16-9-17(29)12-24-16/h4-5,10-11,13,16-17,24H,3,6-9,12,14H2,1-2H3/t16-,17-/m1/s1
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PC sid
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Similars

Article
PubMed
n/an/a 2.40n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
BindingDB Entry DOI: 10.7270/Q2VM4CCK
More data for this
Ligand-Target Pair