BindingDB logo
myBDB logout

BDBM50308560 3-(2-(2-hydroxyethylamino)ethylamino)-1-(2-propoxyethyl)-7-(6-methoxypyridin-3-yl)-1,2-dihydropyrido[3,4-b]pyrazin-2-ol::CHEMBL591477

SMILES: CCCOCCn1c2cc(ncc2nc(N2CCNCC2)c1=O)-c1ccc(OC)nc1

InChI Key: InChIKey=QZRFBQWPAKTWDH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50308560   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50308560
PNG
(3-(2-(2-hydroxyethylamino)ethylamino)-1-(2-propoxy...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCNCC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C22H28N6O3/c1-3-11-31-12-10-28-19-13-17(16-4-5-20(30-2)25-14-16)24-15-18(19)26-21(22(28)29)27-8-6-23-7-9-27/h4-5,13-15,23H,3,6-12H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 670n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch-clamp method


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
BindingDB Entry DOI: 10.7270/Q2VM4CCK
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50308560
PNG
(3-(2-(2-hydroxyethylamino)ethylamino)-1-(2-propoxy...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCNCC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C22H28N6O3/c1-3-11-31-12-10-28-19-13-17(16-4-5-20(30-2)25-14-16)24-15-18(19)26-21(22(28)29)27-8-6-23-7-9-27/h4-5,13-15,23H,3,6-12H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.30n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
BindingDB Entry DOI: 10.7270/Q2VM4CCK
More data for this
Ligand-Target Pair