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BDBM50308563 3-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)-1-(2-propoxyethyl)-7-(6-methoxypyridin-3-yl)pyrido[3,4-b]pyrazin-2(1H)-one::CHEMBL590037

SMILES: CCCOCCn1c2cc(ncc2nc(N2CCN(CC(C)(C)O)CC2)c1=O)-c1ccc(OC)nc1

InChI Key: InChIKey=QYCPKCWJSXULEG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308563   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50308563
PNG
(3-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)-1-(...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CC(C)(C)O)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C26H36N6O4/c1-5-13-36-14-12-32-22-15-20(19-6-7-23(35-4)28-16-19)27-17-21(22)29-24(25(32)33)31-10-8-30(9-11-31)18-26(2,3)34/h6-7,15-17,34H,5,8-14,18H2,1-4H3
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MMDB

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Similars

Article
PubMed
n/an/a 0.210n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
BindingDB Entry DOI: 10.7270/Q2VM4CCK
More data for this
Ligand-Target Pair