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BDBM50311292 CHEMBL1077512::N-(2-cyanophenyl)pyrazolo[1,5-a]pyridine-3-carboxamide

SMILES: O=C(Nc1ccccc1C#N)c1cnn2ccccc12

InChI Key: InChIKey=SJTYXICMAFQVBM-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50311292   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311292
PNG
(CHEMBL1077512 | N-(2-cyanophenyl)pyrazolo[1,5-a]py...)
Show SMILES O=C(Nc1ccccc1C#N)c1cnn2ccccc12
Show InChI InChI=1S/C15H10N4O/c16-9-11-5-1-2-6-13(11)18-15(20)12-10-17-19-8-4-3-7-14(12)19/h1-8,10H,(H,18,20)
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Bioorg Med Chem Lett 19: 6122-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.010
BindingDB Entry DOI: 10.7270/Q2T43T66
More data for this
Ligand-Target Pair