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BDBM50311307 5-(benzyloxy)-N-(2-chlorophenyl)pyrazolo[1,5-a]pyridine-3-carboxamide::CHEMBL1078726

SMILES: Clc1ccccc1NC(=O)c1cnn2ccc(OCc3ccccc3)cc12

InChI Key: InChIKey=UYOQRNSCWIITKH-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50311307   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311307
PNG
(5-(benzyloxy)-N-(2-chlorophenyl)pyrazolo[1,5-a]pyr...)
Show SMILES Clc1ccccc1NC(=O)c1cnn2ccc(OCc3ccccc3)cc12
Show InChI InChI=1S/C21H16ClN3O2/c22-18-8-4-5-9-19(18)24-21(26)17-13-23-25-11-10-16(12-20(17)25)27-14-15-6-2-1-3-7-15/h1-13H,14H2,(H,24,26)
PDB
MMDB

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PC sid
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Similars

Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Bioorg Med Chem Lett 19: 6122-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.010
BindingDB Entry DOI: 10.7270/Q2T43T66
More data for this
Ligand-Target Pair