BDBM50311609 CHEMBL1080444::N-((1S,3S)-3-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)cyclopentyl)-4-(benzo[b]thiophen-2-yl)picolinamide

SMILES Nc1nc(=O)n(cc1F)[C@H]1CC[C@@H](C1)NC(=O)c1cc(ccn1)-c1cc2ccccc2s1

InChI Key InChIKey=YBTIDKMFVSZULE-HOTGVXAUSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50311609   

TargetDeoxycytidine kinase(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311609(CHEMBL1080444 | N-((1S,3S)-3-(4-amino-5-fluoro-2-o...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human deoxycytidine kinase by lysate filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxycytidine kinase(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311609(CHEMBL1080444 | N-((1S,3S)-3-(4-amino-5-fluoro-2-o...)
Affinity DataEC50:  17nMAssay Description:Inhibition of deoxycytidine kinase in anti CD3 and anti CD28 -stimulated human T cells assessed as reduction in [3H]deoxycitidine incorporationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxycytidine kinase(Mus musculus)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311609(CHEMBL1080444 | N-((1S,3S)-3-(4-amino-5-fluoro-2-o...)
Affinity DataEC50:  90nMAssay Description:Inhibition of deoxycytidine kinase in anti CD3 and anti CD28 -stimulated mouse T cells assessed as reduction in [3H]deoxycitidine incorporationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxycytidine kinase(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311609(CHEMBL1080444 | N-((1S,3S)-3-(4-amino-5-fluoro-2-o...)
Affinity DataEC50:  17nMAssay Description:Inhibition of deoxycytidine kinase-mediated arabinoside C-induced cytotoxicityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed