BDBM50312683 2-(4-(2-(trifluoromethyl)phenylthio)piperidin-1-yl)thiazole-5-carboxamide::CHEMBL1076688

SMILES NC(=O)c1cnc(s1)N1CCC(CC1)Sc1ccccc1C(F)(F)F

InChI Key InChIKey=VXTIWKKEIPKNMR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50312683   

TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312683(2-(4-(2-(trifluoromethyl)phenylthio)piperidin-1-yl...)
Affinity DataIC50:  24nMAssay Description:Inhibition of SCD1 in human HepG2 cells assessed as [14C]stearic acid to [14C]oleic acid conversion pretreated 15 mins before [14C]stearic acid addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312683(2-(4-(2-(trifluoromethyl)phenylthio)piperidin-1-yl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed