BDBM50312882 4-(4-(3,4-dichlorophenyl)thiazol-2-ylamino)phenol::CHEMBL1081482

SMILES Oc1ccc(Nc2nc(cs2)-c2ccc(Cl)c(Cl)c2)cc1

InChI Key InChIKey=GBAUSGFNQZAZEH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50312882   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50312882(4-(4-(3,4-dichlorophenyl)thiazol-2-ylamino)phenol ...)
Affinity DataIC50:  30nMAssay Description:Inhibition of partially purified recombinant 5-lipoxygenase (unknown origin) using arachidonic acid as substrate preincubated for 15 mins before subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50312882(4-(4-(3,4-dichlorophenyl)thiazol-2-ylamino)phenol ...)
Affinity DataIC50:  430nMAssay Description:Inhibition of VCP assessed as conversion of ATP to ADP by enzyme coupled glucokinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50312882(4-(4-(3,4-dichlorophenyl)thiazol-2-ylamino)phenol ...)
Affinity DataIC50:  900nMAssay Description:Inhibition of 5-lipoxygenase in human PMNL using arachidonic acid as substrate preincubated for 15 mins before substrate addition measured after 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed