Found 4 hits for monomerid = 50313524 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313524
 (3,5-dioxo-4-(3-(piperidin-1-yl)propyl)-2-(3-(trifl...)Show SMILES FC(F)(F)c1cccc(c1)-n1nc(C#N)c(=O)n(CCCN2CCCCC2)c1=O Show InChI InChI=1S/C19H20F3N5O2/c20-19(21,22)14-6-4-7-15(12-14)27-18(29)26(17(28)16(13-23)24-27)11-5-10-25-8-2-1-3-9-25/h4,6-7,12H,1-3,5,8-11H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116 BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Cathepsin S
(Homo sapiens (Human)) | BDBM50313524
 (3,5-dioxo-4-(3-(piperidin-1-yl)propyl)-2-(3-(trifl...)Show SMILES FC(F)(F)c1cccc(c1)-n1nc(C#N)c(=O)n(CCCN2CCCCC2)c1=O Show InChI InChI=1S/C19H20F3N5O2/c20-19(21,22)14-6-4-7-15(12-14)27-18(29)26(17(28)16(13-23)24-27)11-5-10-25-8-2-1-3-9-25/h4,6-7,12H,1-3,5,8-11H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description Inhibition of cathepsin S |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116 BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this Ligand-Target Pair | |
Cathepsin L1
(Homo sapiens (Human)) | BDBM50313524
 (3,5-dioxo-4-(3-(piperidin-1-yl)propyl)-2-(3-(trifl...)Show SMILES FC(F)(F)c1cccc(c1)-n1nc(C#N)c(=O)n(CCCN2CCCCC2)c1=O Show InChI InChI=1S/C19H20F3N5O2/c20-19(21,22)14-6-4-7-15(12-14)27-18(29)26(17(28)16(13-23)24-27)11-5-10-25-8-2-1-3-9-25/h4,6-7,12H,1-3,5,8-11H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description Inhibition of cathepsin L |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116 BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this Ligand-Target Pair | |
Cathepsin (B and K)
(Homo sapiens (Human)) | BDBM50313524
 (3,5-dioxo-4-(3-(piperidin-1-yl)propyl)-2-(3-(trifl...)Show SMILES FC(F)(F)c1cccc(c1)-n1nc(C#N)c(=O)n(CCCN2CCCCC2)c1=O Show InChI InChI=1S/C19H20F3N5O2/c20-19(21,22)14-6-4-7-15(12-14)27-18(29)26(17(28)16(13-23)24-27)11-5-10-25-8-2-1-3-9-25/h4,6-7,12H,1-3,5,8-11H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description Inhibition of cathepsin B |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116 BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this Ligand-Target Pair | |