BDBM50313629 (6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-7-(4-fluorophenyl)-2-(4H-1,2,4-triazol-4-yl)tetrahydro-1H-pyrrolizin-3(2H)-one::CHEMBL1082896

SMILES C[C@@H](O[C@H]1CN2[C@@H](CC(C2=O)n2cnnc2)[C@@H]1c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=GCUALAPXLAAJSL-UAWOKRSRSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50313629   

TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313629((6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataIC50:  0.0700nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313629((6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313629((6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313629((6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataIC50:  0.0700nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed