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BDBM50316889 2-amino-4-phenyl-8-(2-(pyrrolidin-1-yl)ethoxy)-5H-indeno[1,2-d]pyrimidin-5-one::CHEMBL1095490

SMILES: Nc1nc2-c3cc(OCCN4CCCC4)ccc3C(=O)c2c(n1)-c1ccccc1

InChI Key: InChIKey=DWAWMNJZTVBRAL-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50316889   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine receptor A2


(Homo sapiens (Human))
BDBM50316889
PNG
(2-amino-4-phenyl-8-(2-(pyrrolidin-1-yl)ethoxy)-5H-...)
Show SMILES Nc1nc2-c3cc(OCCN4CCCC4)ccc3C(=O)c2c(n1)-c1ccccc1
Show InChI InChI=1S/C23H22N4O2/c24-23-25-20(15-6-2-1-3-7-15)19-21(26-23)18-14-16(8-9-17(18)22(19)28)29-13-12-27-10-4-5-11-27/h1-3,6-9,14H,4-5,10-13H2,(H2,24,25,26)
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PC cid
PC sid
UniChem

Similars

Article
PubMed
19.3n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonistic activity at adenosine A2A receptor


Bioorg Med Chem Lett 20: 2868-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.024
BindingDB Entry DOI: 10.7270/Q27S7NXB
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50316889
PNG
(2-amino-4-phenyl-8-(2-(pyrrolidin-1-yl)ethoxy)-5H-...)
Show SMILES Nc1nc2-c3cc(OCCN4CCCC4)ccc3C(=O)c2c(n1)-c1ccccc1
Show InChI InChI=1S/C23H22N4O2/c24-23-25-20(15-6-2-1-3-7-15)19-21(26-23)18-14-16(8-9-17(18)22(19)28)29-13-12-27-10-4-5-11-27/h1-3,6-9,14H,4-5,10-13H2,(H2,24,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
159n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonistic activity at adenosine A1 receptor


Bioorg Med Chem Lett 20: 2868-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.024
BindingDB Entry DOI: 10.7270/Q27S7NXB
More data for this
Ligand-Target Pair