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BDBM50317214 (2R)-N-(adamantan-2-yl)-1-(2-methylpropyl)pyrrolidine-2-carboxamide::CHEMBL1098130

SMILES: CC(C)CN1CCC[C@@H]1C(=O)NC1C2CC3CC(C2)CC1C3

InChI Key: InChIKey=PGOYJAUWQHMNDQ-SVXFNXITSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50317214   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50317214
PNG
((2R)-N-(adamantan-2-yl)-1-(2-methylpropyl)pyrrolid...)
Show SMILES CC(C)CN1CCC[C@@H]1C(=O)NC1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C19H32N2O/c1-12(2)11-21-5-3-4-17(21)19(22)20-18-15-7-13-6-14(9-15)10-16(18)8-13/h12-18H,3-11H2,1-2H3,(H,20,22)/t13?,14?,15?,16?,17-,18?/m1/s1
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.0300n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 2897-902 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.032
BindingDB Entry DOI: 10.7270/Q2NV9JDJ
More data for this
Ligand-Target Pair