BDBM50317233 (E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methoxy-7-(4-(4-methylpiperazin-1-yl)but-1-enyl)quinoline-3-carbonitrile::CHEMBL1088240

SMILES COc1cc(Nc2c(cnc3cc(\C=C\CCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl

InChI Key InChIKey=XTMQXGYZVJVLMD-GQCTYLIASA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50317233   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317233((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317233((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317233((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317233((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Affinity DataIC50:  58nMAssay Description:Inhibition of Src-mediated cell proliferation in rat Rat-2 fibroblasts after 4 days by MTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50317233((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317233((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317233((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human recombinant Src after 70 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317233((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TPL2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed