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BDBM50319165 2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine::3,4-Dimethyl-8-methoxy-1-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine::CHEMBL1086110

SMILES: CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12

InChI Key: InChIKey=YNADXFWEXJTQSZ-UHFFFAOYSA-N

Data: 24 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50319165   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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PubMed
n/an/a 919n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE5A


J Med Chem 53: 4399-411 (2010)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 239n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDE2A expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation counti...


J Med Chem 55: 7299-331 (2012)

More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 920n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE5A using [3H]cGMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 690n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE11A using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 7.30n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


J Med Chem 53: 4399-411 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE9A


J Med Chem 53: 4399-411 (2010)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 239n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE2A


J Med Chem 53: 4399-411 (2010)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE4A


J Med Chem 53: 4399-411 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE1B


J Med Chem 53: 4399-411 (2010)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 7B


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 3.10E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE7B


J Med Chem 53: 4399-411 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 3.70E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE3A


J Med Chem 53: 4399-411 (2010)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 32n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Inhibition of PDE10A


Bioorg Med Chem Lett 21: 3738-42 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 7.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant bovine PDE6A using [3H]cGMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 3.35E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE7A using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 270n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE9A using [3H]cGMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE1B using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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MMDB

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n/an/a 7n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDE10A1 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation coun...


J Med Chem 55: 7299-331 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 779n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE11A


J Med Chem 53: 4399-411 (2010)

More data for this
Ligand-Target Pair