BDBM50320369 (R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone::CHEMBL1084738

SMILES C[C@@H]1CN(CCN1c1nnc(-c2ccc(cc2)C(F)(F)F)c2ccccc12)C(=O)c1ccccc1

InChI Key InChIKey=DEEQMQGTBCCINJ-GOSISDBHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50320369   

TargetSmoothened homolog(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)
Affinity DataIC50:  0.00200nMAssay Description:Antagonist activity at mouse cloned Smo receptor expressed in NIH-3T3 cells co expressing Gli1 binding site after 15 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)
Affinity DataIC50:  2.80nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed