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BDBM50320830 CHEMBL4162965

SMILES: OC(=O)CCNC(=O)c1ncc(C(=O)NC(c2ccccc2)c2ccccc2)c(O)n1

InChI Key: InChIKey=DAEBKDLSEJEOPL-UHFFFAOYSA-N

Data: 1 IC50

PDB links: 96 PDB IDs match this monomer.

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50320830   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor prolyl hydroxylase


(Homo sapiens (Human))
BDBM50320830
PNG
(CHEMBL4162965)
Show SMILES OC(=O)CCNC(=O)c1ncc(C(=O)NC(c2ccccc2)c2ccccc2)c(O)n1
Show InChI InChI=1S/C22H20N4O5/c27-17(28)11-12-23-22(31)19-24-13-16(21(30)26-19)20(29)25-18(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-10,13,18H,11-12H2,(H,23,31)(H,25,29)(H,27,28)(H,24,26,30)
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PubMed
n/an/a<20n/an/an/an/an/an/a



Cadila Healthcare Limited

Curated by ChEMBL


Assay Description
Inhibition of FLAG- tagged full length HIF-PHD2 (unknown origin) expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQ...


J Med Chem 61: 6964-6982 (2018)


BindingDB Entry DOI: 10.7270/Q2H70JC7
More data for this
Ligand-Target Pair