BDBM50321627 CHEMBL1171505::CatS_6::N-(2-chloro-5-(4-(3-(4-(6-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-3-oxo-3,4-dihydropyrazin-2-yl)benzyl)-4-fluorobenzamide

SMILES Cn1c2ccc(Cl)cc2n(C2CCN(CCCn3ccnc(-c4ccc(Cl)c(CNC(=O)c5ccc(F)cc5)c4)c3=O)CC2)c1=O

InChI Key InChIKey=MNEPYBOQUOAGHK-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50321627   

TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321627(CHEMBL1171505 | CatS_6 | N-(2-chloro-5-(4-(3-(4-(6...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321627(CHEMBL1171505 | CatS_6 | N-(2-chloro-5-(4-(3-(4-(6...)
Affinity DataIC50:  110nMAssay Description:D3R2020More data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321627(CHEMBL1171505 | CatS_6 | N-(2-chloro-5-(4-(3-(4-(6...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of cathepsin S-mediated invariant chain degradation in human JY B-cells assessed as accumulation of p10 fragment by Western blot analysisMore data for this Ligand-Target Pair