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BDBM50321826 4-(4-((1H-Imidazol-4-yl)methyl)piperidin-1-yl)-N-methylaniline::CHEMBL1169687

SMILES: CNc1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1

InChI Key: InChIKey=NBMDOIDXQULZMB-UHFFFAOYSA-N

Data: 1 KI  1 EC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50321826   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321826
PNG
(4-(4-((1H-Imidazol-4-yl)methyl)piperidin-1-yl)-N-m...)
Show SMILES CNc1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H22N4/c1-17-14-2-4-16(5-3-14)20-8-6-13(7-9-20)10-15-11-18-12-19-15/h2-5,11-13,17H,6-10H2,1H3,(H,18,19)
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KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.60n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321826
PNG
(4-(4-((1H-Imidazol-4-yl)methyl)piperidin-1-yl)-N-m...)
Show SMILES CNc1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H22N4/c1-17-14-2-4-16(5-3-14)20-8-6-13(7-9-20)10-15-11-18-12-19-15/h2-5,11-13,17H,6-10H2,1H3,(H,18,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.70n/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair