BDBM50322427 CHEMBL1172999::rac-Fluoro-4-{4-[5-methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-benzoyl]-piperazin-1-yl}-benzonitrile

SMILES CC(Oc1ccc(cc1C(=O)N1CCN(CC1)c1ccc(cc1F)C#N)S(C)(=O)=O)C(F)(F)F

InChI Key InChIKey=BKVYIWKPPJAXRW-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50322427   

TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50322427(CHEMBL1172999 | rac-Fluoro-4-{4-[5-methanesulfonyl...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50322427(CHEMBL1172999 | rac-Fluoro-4-{4-[5-methanesulfonyl...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50322427(CHEMBL1172999 | rac-Fluoro-4-{4-[5-methanesulfonyl...)
Affinity DataEC50:  44nMAssay Description:Inhibition of human GlyT1b expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed