BDBM50322877 CHEMBL1210329::N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-( PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO) BENZAMIDE::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(N-phenylmethylsulfonamido)benzamide

SMILES C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N(c1ccccc1)S(C)(=O)=O)C(=O)NC1CCCCC1

InChI Key InChIKey=PSSKPAZTPVDDNS-RJSONGRPSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50322877   

TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322877(CHEMBL1210329 | N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLA...)
Affinity DataIC50:  570nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-40 production by cell based assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322877(CHEMBL1210329 | N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLA...)
Affinity DataIC50:  15nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322877(CHEMBL1210329 | N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLA...)
Affinity DataIC50:  655nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322877(CHEMBL1210329 | N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLA...)
Affinity DataIC50:  660nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322877(CHEMBL1210329 | N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLA...)
Affinity DataIC50:  510nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-42 production by cell based assayMore data for this Ligand-Target Pair