BDBM50323101 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(1-(3-(dimethylamino)propyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1209017

SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1cnn(CCCN(C)C)c1)c1ccccc1Cl

InChI Key InChIKey=WAMWLVAINQIUBS-GOSISDBHSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50323101   

TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323101((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(1-(3-(dimet...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human recombinant CYP2C9 using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323101((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(1-(3-(dimet...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PLK1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323101((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(1-(3-(dimet...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human recombinant CYP3A4 using 7-benzyloxyquinoline as substrate by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323101((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(1-(3-(dimet...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human recombinant CYP3A4 using diethoxyfluorescein as substrate by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed